en
With the majority of pMDIs, manual depression of the drug canister actuates
the drug delivery. However, with breath-actuated metered dose inhalers
(e.g. Autohaler™ ), the aerosol is released by mechanical actuation, triggered by
the patient breathing in through the device at any flow rate above a minimum
level. At inspiratory flows below this, the patient will not receive any of the
medication, because a dose will not be released.
pMDIs with Holding Chamber/Spacer
It is recognised that the optimum inhalation technique for using a pMDI with a
holding chamber/spacer is a slow inhalation (30 to 60 l/min). As the resistances
of the values of most chamber/spacer devices are low, the In-Check DIAL G16
can be set to "conventional pMDI" to provide an approximate resistance
for inspiratory flow measurements to be made.
Dry Powder Inhalers (DPIs)
Drug delivery from DPIs is triggered by inhaling through the device. Turbulent
airflows cause a metered quantity of powder to be drawn into the airflow, and
follow a specific pathway within the inhaler, through internal features that create
a resistance that is designed to break up the medication into particles of a
respirable size.
As the internal design of each DPI is different, and the formulation of medication
is not identical, the resistance the patient encounters when inhaling is different
from device to device.
The effort required for the patient to achieve a given inspiratory flow will increase
as the internal resistance of the device increases. For the same patient effort, the
higher the resistance the lower the resulting inspiratory flow.
As the great majority of asthma medication is delivered via inhalers, correct
inhaler technique is an important factor in the management of this disease.
Patients require their medication for both short-term relief and long-term
prevention, and the delivery of these drugs to the lungs is affected by
inspiratory flow. Assessing inspiratory flow is an important aspect of device
education and review. Determining whether or not a patient can obtain the
appropriate inspiratory flow rate for a device can be an important factor in
improving inhaled treatment.
In-Check DIAL
G16
In-Check DIAL G16 is a low-range inspiratory flow meter (15 to 120 l/min) that
has a selectable resistance from high to low, shown by the coloured 'flow' icons
on the accompanying laminated card, calibrated to enable the measurement of
airflow as if the patient was using certain different inhalers.
(see laminated card).
The "conventional pMDI" position can be used to approximate the
resistance when a conventional pMDI is attached to a holding chamber or
spacer device.
In-Check DIAL G16 provides a measurement of inspiratory flow through
five classes of device resistance. However, the resistance is not precise
for all inhalers, e.g. the resistance of the Genuair is slightly lower than the
resistance of the Turbohaler Mk III, but they are both medium resistance
inhalers. To mimic the precise resistance of a particular inhaler, specific
adaptors are available to use with the DIAL set to 'conventional pMDI'.
Should new types of inhaler become available, then In-Check DIAL G16
can be used to measure the new inspiratory flow, by knowing the
resistance of the new inhaler.
3