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• Permanent changes in pigmentation: Both hypopigmentation (lightening of the skin) and
hyperpigmentation (darkening of the skin) may occur after cryotherapy. Both generally last a few months,
but can be longer lasting. Avoid freezing the basal cell layer where melanocytes (pigment producing cells)
are located.
• Sensory impairment: Though rare, damage to nerves is possible, particularly in areas where they lie closer
to the surface of the skin, such as the fingers, the wrist, and the area behind the ear. Reports suggest this will
disappear within several months.
• Spattering of the cryogen during spraying, when the end nozzle freezes: The innovation of CryoProbe
is the direct application of nitrous oxide under high pressure (50-55 bar). This high pressure jet may cause
minor shards of frozen humidity in the air blown away in a circle of approximately 30cm of diameter. They will
thaw the moment they would eventually touch healthy skin.
• Hair loss: Hair follicles are easily damaged by cryosurgery and permanent hair loss is not uncommon.
• Pigmented spots. It is common use to not treat pigmented spot in sunny seasons:
Solar lentigines (SL) are flat brown sharply demarcated pigmented lesions that commonly appear as a sign of
aging and photodamage on sun-exposed skin.
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