Waters HPLC Diagnóstico Y Corrección De Anomalías página 78

De De- - Wetting Wetting
"Hydrophobic Collapse" "Hydrophobic Collapse"
•"Hydrophobic Collapse" is a term that has commonly
been used to describe the loss of retention in RP
Chromatography.
It refers to the long C It refers to the long C
down to the particle surface, thereby not being fully
extended to interact, or retain the analyte.
•In reality, it is the de-wetting of the pores which causes
the loss of retentivity.
Chains folding or collapsing back Chains folding or collapsing back
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